Saturday, April 13, 2013

Diagnosis of Kidney Disease


The kidneys are organs whose main task of purifying blood of harmful products of metabolism, and the regulation of water in the body. This also means that it is highly vascularized organs through which pass every minute fifth of the total blood volume. At the intersection of the kidney can distinguish two anatomical areas: the crust and the core. 



Crust consists mainly renal glomeruli, which represent a large number of tiny filters through which purifies the blood. Chronic glomerulonephritis characterized by diffuse scarring changes in the glomeruli, whose wall is thickened and connective changed. Simply put, we can say that there is a flaw in the grid glomeruli, which is why it comes out in the urine and substances that are beneficial organism (proteins) and that it would not filtered. So in laboratory analysis of urine sediment found in protein, casts and blood. It leads to the gradual loss of kidney function over a long period of time, so it may take several months or years before they become symptomatic. It is likely that there are several causes that may lead to chronic glomerulonephritis. Immune complexes on the walls of the glomeruli can be seen in this disease, but they are probably the result not the cause. Only rarely in history may encounter suffered acute glomerulonephritis. The disease usually reveals abnormal laboratory findings in the sediment of urine during a routine medical examination. Sometimes patients come because they noticed blood in the urine. Blood pressure is often elevated.

Search on blood urea and creatinine may show elevated concentrations in their blood. These are the products of protein metabolism that is normally eliminated by the kidneys. Their levels in the blood speaks of the degree of renal impairment. In rare cases, patients come with nausea, vomiting, itching and skin discoloration as a reflection of the advanced stages. Diagnosis is based on the pathological findings in urine and blood, and in doubtful cases confirms the possible kidney biopsy. Treatment of this disease is to control drug-pressure, and dietary recommendations is limited primarily in terms of protein and salt intake. In advanced cases of terminal renal failure there is a need for hemodialysis (artificial kidney) and subsequent renal transplantation. 

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